Abstract
Abstract The metabolism in mouse and chick embryo fibroblast cultures of the purine nucleoside analogue 7-deazanebularin has been studied. The analogue is cytotoxic at low concentrations, it is rapidly phosphorylated and enters the cellular nucleotide pools, and it is incorporated into cellular DNA and RNA. A substantial proportion of the incorporated material is present at the 3' termini of tRNA molecules. 7-Deazanebularin is also incorporated into the RNA of Mengovirus and the DNA of vaccinia virus, and it strongly inhibits cellular and viral nucleic acid synthesis.
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