Abstract
The Allis group identified Gcn5 as the first transcription-related lysine acetyltransferase in 1996, providing a molecular ‘missing link’ between chromatin organization and gene regulation. This review will focus on functions subsequently identified for Gcn5 and the closely related PCAF protein, in the context of two major complexes, SAGA and ATAC, and how the study of these enzymes informs long standing questions regarding the importance of lysine acetylation.
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