Abstract
Urate-lowering therapy (ULT) is central to the management of hyperuricemia in gout. The goal of ULT in gout is to reduce the frequency of acute flares and prevent progressive joint destruction and tophaceous deposition. This goal can be achieved by lowering and maintaining serum urate (sUA) concentrations to less than 5 to 6 mg/dL. Optimal ULT requires careful patient selection with attention to comorbid illness, ongoing education, adoption of a treat-to-target approach, and effective anti-inflammatory prophylaxis with treatment initiation.
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