6 - Drug combinations

Abstract

Most cancers have multiple genetic alterations and molecular abnormalities. It is seldom very useful by using only one anticancer drug owing to refractory and drug resistance of cancer tissues. Anticancer drug cocktail instead single drugs might dramatically promote the control of cancer progresses and metastasis in different patients. Despite it becomes a modern cliché that anticancer drug combination is better than single anticancer drug, how to combinative utilizations of anticancer drug cocktails is a new series of problems and solutions in new era of anticancer therapy studies. Most important, anticancer drug cocktails need transformation from empirical to science-guided systems. This chapter pictures the scenarios and landscapes of present and future knowledge of cancer therapy, especially possible future solutions for overcoming weaknesses, limitations, pitfalls and drawbacks of past cancer therapy and create more matured ones.