Abstract
Most cancers have multiple genetic alterations or abnormalities. It is seldom very useful by only using one anticancer drug. Human cancer is a refractory and resistant disease, and like HIV virus, it might need anticancer drug cocktail, instead single drugs to dramatically control the progresses of the disease. Anticancer drug cocktail might be one of the good solutions for anticancer chemotherapy. How to combine use of anticancer drugs is a new problem and area of anticancer drug therapy. This editorial addresses this problem in depth.
Highlights
Most cancers have multiple genetic alterations or abnormalities
It is the cytotoxic chemical drugs to reduce tumor to a minimum volume, high specific biotherapy to kill the rest of tumor cells, no matter these tumor cells are multidrug resistance (MDR) or not
Human cancer metastasis encompasses several different substages (1) invade locally through surrounding extracellular matrix (ECM) and stromal cell layers, (2) intravasate into the lumina of blood vessels; (3) tumor cells survive the rigors of transport through the vasculature; (4) arrest at distant organ sites; (5) tumor cells extravasate into the parenchyma of distant tissues; (6) initially survive in these foreign microenvironments in order to form micrometastases, and (7) reinitiate their proliferative programs at distant sites, thereby generating macroscopic, clinically detectable neoplastic growths [69]
Summary
Da-Yong Lu1*, Ting-Ren Lu2 and Shan Cao3 1Shanghai University, Shanghai 200444, PR China 2College of Science, Shanghai University, Shanghai 200444, PR China 3Zhong-Guo High School, Xu-Hui District, Shanghai, PR China.
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