563P Single-cell profiling analysis reveals that AIF1-induced M2-to-M1 transition of macrophages suppresses the expression of HPV oncogenes and the progression of cervical carcinoma

Abstract

Although macrophages have been identified as a regulator of tumor immunity and immunotherapy in many cancer types, with M2-polarized macrophages being reputed to facilitate tumor progression, the mechanisms of M1-M2 transition in human papillomavirus (HPV) carcinogenesis and tumor immunity remained to be determined.