Abstract
Non-coding RNAs (ncRNAs) can be divided into circular non-coding RNAs (circRNAs) and linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and immunocytes. Linear ncRNAs, such as long ncRNAs and microRNAs, have been found to play important roles in the regulation of tumor immunity and immunotherapy; however, the functions of circRNAs in tumor immunity and immunotherapy are less known. Here, we review the current status of ncRNAs in the regulation of tumor immunity and immunotherapy and emphatically discuss the potential roles of circRNAs as tumor antigens in the regulation of tumor immunity and immunotherapy.
Highlights
Frontiers in ImmunologyThe Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy
Non-coding RNAs, mainly including microRNAs, long non-coding RNAs, and circular RNAs, constitute approximately 95% of total RNAs in eukaryotic cells [1] and have important physiological functions in gene regulation [2]
HOTTIP), transcriptional (7SK, SRA, PCAT-1, and GAS5) and posttranscriptional (MALAT1, 1/2-sbsRNAs, NEAT) levels through interacting with different types of molecules, such as miRNAs, mRNAs, and even proteins [48,49,50]. long non-coding RNAs (lncRNAs) are differentially expressed between various tissues or developmental stages and participate in the physiological activities of normal cells, tumor cells, and cells involved in different diseases
Summary
The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy. Non-coding RNAs (ncRNAs) can be divided into circular non-coding RNAs (circRNAs) and linear ncRNAs. ncRNAs exist in different cell types, including normal cells, tumor cells and immunocytes. Linear ncRNAs, such as long ncRNAs and microRNAs, have been found to play important roles in the regulation of tumor immunity and immunotherapy; the functions of circRNAs in tumor immunity and immunotherapy are less known. We review the current status of ncRNAs in the regulation of tumor immunity and immunotherapy and emphatically discuss the potential roles of circRNAs as tumor antigens in the regulation of tumor immunity and immunotherapy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
