Abstract
It is well accepted today that almost cases of carcinoma of the cervix are caused by persistent infections with human papilloma viruses (HPV), especially high risk HPV(HR-HPV)-16, -18 which accounting for more than 70%. The prevention of HPV infection in the development and progression of cervical carcinoma is very important. The success of HPV vaccine development has made great breakthrough in the prevention of cervical carcinoma. At present, two kinds of HPV vaccine were widely used in the world. They are Gardasil○R (anti-HPV-6, -11, -16, -18, Merck & Co., Inc., USA) and Cervarix™ (anti-HPV-16, -18, GlaxoSmithKline, England). This paper focused on the carcinogenesis and epidemiological situation of HPV, the mechanism and safety of preventive HPV vaccine. Key words: human papillomavirus infection; preventive vaccine
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