Abstract
Horse chestnut (Aesculus hippocastanum) is a species of flowering plant in the Sapindaceae family with clinical evidence for chronic venous insufficiency (CVI). In addition to benefits for CVI, clinical trials indicate that horse chestnut seed extract (HCSE) or its constituent escin may be beneficial for hearing loss and varicocele-related infertility. Escin has been shown to have anti-inflammatory, neuroprotective, and antitumor effects. HCSE has venotonic, vascular protective, antispasmodic, anti-edematous, anti-allergic, anti-inflammatory, astringent, vasodilator, bitter, and diuretic properties. This chapter examines some of the scientific research conducted on horse chestnut, both alone and in combination formulas, for treating numerous health conditions. It summarizes results from several human studies of horse chestnut’s use in treating ENT, cardiovascular, genitourinary, and dermatologic disorders. Finally, the chapter presents a list of horse chestnut’s active constituents, different Commonly Used Preparations and Dosage, and a section on “Safety and Precaution” that examines side effects, toxicity, and disease and drug interactions.
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