Abstract
The increase in DT diaphorase activity after treatment of rats with 3-Meyhylcholantrene (MC) seems to be due to an induced enzyme synthesis. Not only liver but also other tissues show an increased DT diaphorase activity after MC-treatment. This increase parallels that of the aryl hydrocarbon monooxygenase (AHM) activity except in heart, where only DT diaphorase activity increases. This indicates a difference in gene expression between the inductions of DT diaphorase and the AHM system. Microsomal hydroxylation of benzo(a)pyrene (BP) leads to an inhibition of DT diaphorase with a simultanous decrease in dicoumarol sensitivity of the enzyme. Probably a product of BP metabolism is responsible for these effects.
Published Version
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