Abstract
The increase in DT diaphorase activity after treatment of rats with 3-Meyhylcholantrene (MC) seems to be due to an induced enzyme synthesis. Not only liver but also other tissues show an increased DT diaphorase activity after MC-treatment. This increase parallels that of the aryl hydrocarbon monooxygenase (AHM) activity except in heart, where only DT diaphorase activity increases. This indicates a difference in gene expression between the inductions of DT diaphorase and the AHM system. Microsomal hydroxylation of benzo(a)pyrene (BP) leads to an inhibition of DT diaphorase with a simultanous decrease in dicoumarol sensitivity of the enzyme. Probably a product of BP metabolism is responsible for these effects.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
