Abstract
We have developed a method that allows biological tissues to adhere together with minimal invasion by delivering integrated low-level energies such as heat, pressure, and vibration. The adhesion mechanism was investigated by observing collagen fibril's change under the influence of heat and pressure by atomic force microscopy and scanning electron microscopy. When collagen fibrils were treated with heat at temperatures above 63℃ in dehydrated nvironment, some collagen fibrils with diameters above 1000 nm were observed by atomic force microscopy. Furthermore, when application of pressure of 2 MPa and application of heat were applied simultaneously on collagen fibrils at temperatures above 63℃ in dehydrated environment, aggregation of collagen fibrils was observed by scanning electron microscopy. Since thick collagen fibrils have higher mechanical strength, application of pressure of 2 MPa and application of heat at temperatures above 63℃ applied on biological tissues were expected to lead to adhere biological tissues together tenaciously by proposed method.
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