504 PVRIG, a novel T cell checkpoint, is preferentially expressed in TLS on stem-like memory T cells, potentially inhibiting their expansion

Abstract

<h3>Background</h3> Tertiary lymphoid structures (TLS) recently emerged as an intra-tumoral niches of immune-cell aggregates with a predictive value for cancer immunotherapy responses.¹ LAMP3⁺DCs in the TLS were shown to interact...