5 - Optical Imaging Based on Intrinsic Signals

Abstract

Optical imaging based on intrinsic signals is unique among functional neuroimaging techniques in that it offers both high spatial and high temporal resolution simultaneously. Moreover, no other functional neuroimaging technique offers comparable spatial resolution, allowing visualization of the fine structure of individual functional domains within cortical areas. Additionally, high spatial resolution maps can be acquired over relatively large cortical areas. The resolution of optical imaging makes it ideal for a variety of experimental investigations, including studying the functional organization of and functional relationships within the brain, characterizing neurovascular physiology, and examining pathophysiological changes due to certain disease processes. One of the more significant applications of optical imaging of intrinsic signals is studying the human cortex. This not only allows characterizing the physiology and functional architecture of the human brain, but may also be clinically useful as an intraoperative functional brain mapping tool for neurosurgical guidance.