Abstract
This chapter focuses on electroencephalogram (EEG) findings to illustrate changes in the central nervous system (CNS) function produced by psychotropic medications. The EEG is used in two quite distinct ways in the study of medication effects. The computer analysis of the EEG activity demonstrates combinations of changes in the different frequency bands, which has proved useful in comparison of different compounds and subsequent identification of new compounds of potential clinical value. The computer analysis of acute drug effects should be recognized as quite different from the EEG changes expected in a patient routinely taking these medicines and the changes seen in visually interpreted EEG, read by clinical standards without serial record comparisons. In visually interpreted EEGs, chronic use of neuroleptic and antidepressant drugs has relatively little effect on the EEG, except when they have a hypnotic effect, which changes the level of consciousness or when they have a toxic effect producing the expected changes of toxicity.
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