Abstract
Because of its unique cationic character, chitosan can interact with anionic polymers to form polyelectrolyte complexes (PECs). These complexes, thanks to their easy preparation, biocompatibility, and pH sensitivity, have been widely studied as excipients for the formulation of active agents in multiple drug delivery systems. This chapter summarizes the aspects of drug delivery by PEC obtained by complexation of unmodified chitosan with natural polysaccharides or their derivatives, such as chondroitine sulfate, carboxymethyl starch, dextran sulfate, pectin, and alginate. This review specifically describes the role of polymeric excipients in the control of drug release.
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