3D bioprinting: from the functional restitution of organs and tissues to the modeling of chronic degenerative diseases

Abstract

In order to overcome the long wait of patients in queues to receive a donated organ and the advancement of chronic degenerative diseases, regenerative medicine introduced 3D bioprinting. This study aims to expose the possibilities arising from the use of 3D bioprinting in organ transplantation and in the modeling of chronic degenerative diseases. A bibliographic review was carried out using the PubMed and SciELO databases, published between 1993 (due to its relevance) and 2023, no language restriction. By exploring the techniques, it was observed that biomodels created in vivo and in vitro, especially from induced pluripotent stem cells (iPSCs), the main target of this study, mimicked the architecture and physiology of bone, liver, heart tissue and even neural progenitor cells, which impact on the modeling of Parkinson's and Alzheimer's diseases. Despite the existing challenges to reproducing functional organs on a clinical scale, 3D bioprinting is a promising technology that promises to revolutionize the field of regenerative medicine and resolve, in a few years, these obstacles that cause high morbidity and mortality.