Abstract
regionand layer-specific activities in the human intestine. Its inhibitory effect involved decreased intracellular calcium level via closure of SOCs that belong to the TRPC3/TRPA1 family. Apart from milk thistle and iberis amara, all extracts contributed to the effects of STW5. Peppermint, angelica and liquorice mimicked its inhibitory action on muscle activity. The identification of region and target specific actions of STW5 and its components suggests their potential for treating small and large intestinal motility disorders.
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