307P - Lacrimal gland tumours: Clinical and epidemiological patterns in the United States

Abstract

BackgroundLacrimal gland is an exocrine secretory gland located at the upper temporal fossa of the orbit. It is part of the tear-forming apparatus that constitutes an important orbital structure. However, data available about tumors possibly originating in this site are scarce. In this study, we aimed to spotlight on this rare type of malignancy using the using data from American National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) Program. MethodsWe used SEER*Stat version 8.3.4, Microsoft Excel, as well as SPSS IBM SPSS Statistics for Windows, Version 21.0. In SEER*Stat, we used the (Incidence - SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2015 Sub (1973-2013 varying)) database. We included SEER 18 cases that were diagnosed after 2003 (2004+) in which the primary site was identified as (C69.5 – Lacrimal gland). Only cases with malignant behavior, known age, and those in the Research Database were included. ResultsA total of 491 cases were identified with a median age of 63. Females represented the majority of the analyzed cohort (n = 263, 53.6%). Lacrimal gland tumors were most common among the white race (n = 376, 76.6%). Age-adjusted Incidence rate was 0.6 per 1,000,000 with a median survival of 41 months, while 5-year relative survival was 88.4% (CI: 81.9% - 92.6%). The most common pathology of studied cases was Non-Hodgkin lymphoma (n = 254, 51.7%) (Table).Table307P Different pathological subtypes for lacrimal gland tumoursTablePathological SubtypeN.%NHL-Mature B-Cell Lymphomas25451.7 %Squamous Cell Neoplasms7114.5 %Adenomas &Adenocarcinomas6413.0 %Malignant Lymphomas, NOS Or Diffuse326.5 %Mucoepidermoid Neoplasms173.5 %Epithelial Neoplasms, NOS102.0 %Nevi Melanomas81.6 %Ductal & Lobular Neoplasms71.4 %Lymphoid Leukemias (C42.1)61.2 %Transitional Cell Papillomas & Carcinomas40.8 %Complex Mixed & Stromal Neoplasms40.8 %Myomatous Neoplasms30.6 %Basal Cell Neoplasms20.4 %Complex Epithelial Neoplasms20.4 %Plasma Cell Tumors20.4 %Unspecified Neoplasms10.2 %Cystic, Mucinous & Serous Neoplasms10.2 %Fibromatous Neoplasms10.2 %Hodgkin Lymphomas10.2 %Nhl-Mature T & Nk-Cell Lymphomas10.2 % ConclusionsLacrimal gland tumors are extremely rare with incidence rate of 0.6 per million. These tumors are more likely to occur in old age, females, white race. 5-years relative survival is 88.4% with a median survival of 41 months. Legal entity responsible for the studyThe authors. FundingHas not received any funding. DisclosureAll authors have declared no conflicts of interest.