PB2056 ORBITAL LYMPHOMA: CLINICAL AND EPIDEMIOLOGICAL PATTERNS WITHIN THE UNITED STATES

Abstract

Background:Lymphomas are relatively common tumors that may affect the orbit through tissue infiltration. However, data available about tumors possibly originating in orbit (also called orbital lymphoma) are scarce.Aims:In this study, we aimed to spotlight on this type of malignancy using the using data from American National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) Program.MethodsWe used SEER∗Stat version 8.3.5, Microsoft Excel, as well as SPSS IBM SPSS Statistics for Windows, Version 25.0 for data analysis. In SEER∗Stat, we used the (Incidence ‐ SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2017 Sub (1973‐2015 varying)) database to obtain data. We included cases diagnosed with lymphoma between 2006 and 2015 at site related to orbital cavity C69.0‐C69.9.Results:A total of 2340 cases were identified with a median age of 65.2. Females and patients of white race represented the majority of the analyzed cohort (n = 1249, 53.4%; n = 1846, 78.9%, respectively). Age‐adjusted Incidence rate was 3 per 10,000. 5‐years observed survival was 82% (95% CI: 79.8% ‐ 84%) while the 5‐years relative survival was 94.3% (95% CI: 91.3% ‐ 96.2%). The most common pathology of studied cases was extranodal marginal zone lymphoma of mucosal‐associated lymphoid tissue (MALT) (n = 1310, 56%) [Table 1]. Median survival was not reached at the study cutoff (Figure 1).Summary/Conclusion:Orbital lymphoma has an incidence rate of 3 per 10,000. These tumors are more likely to occur in old age, females, and white race. Survival data are relatively good with the 5‐years relative survival being 94.3%.image