3 - Synthesis of azetidines by metal-catalyzed cycloaddition of imines to alkenes

Abstract

Various wider aspects of heterocyclic chemistry are known as disciplines of usual importance that impose on nearly all characteristics of modern medicinal chemistry, biochemistry, and organic chemistry. The derivatives of heterocyclic compounds constitute a predictable part of a broad range of pharmacologically active natural and pharmaceutically important compounds. Azetidines have attracted significant attention in synthetic organic chemistry due to the important biological activities of these saturated 4-membered N-heterocyclic compounds. Being a structural unit, β-lactams are found in broadly utilized antibiotics and occupy a basic position in pharmaceutical chemistry for over a hundred years now.