Abstract
Being a structural unit, β-lactams are found in broadly utilized antibiotics and occupy a basic position in pharmaceutical chemistry for over a hundred years now. There are various approaches for the formation of azetidinone ring, for instance, Rh-catalyzed carbonylation of an aziridine, Rh-catalyzed intramolecular insertion of α-diazo amide into a carbon-hydrogen bond, Cu-catalyzed coupling of an alkyne with nitrone, amino-ether-catalyzed reaction between ester enolates and imines, and ketene-imine cycloaddition. Among these, an anellation of acetyl chlorides with imines has been verified to be a convenient and versatile method.
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