2‐Alkenyl Furans from a Palladium‐Catalyzed Cyclization and Coupling of Ene‐Yne‐Ketones

Abstract

The expedient synthesis of substituted aromatic heterocycles has been a major goal for organic chemistry for decades, owing to the bioactive properties of heterocycles and their prevalence in natural products. As such, the development of new methods to synthesize heterocycles has been at the forefront of our discipline. Of these techniques, transition metalcatalyzed reactions are among the most important in the development of new technologies for the synthesis of heterocycles. In recent years, transition metal-catalyzed coupling reactions involving diazo compounds or N-tosylhydrazones have facilitated the generation of metal carbene intermediates in situ (Scheme 1). The carbenoid intermediate can then un-