Abstract
Periodontitis is an inflammatory disease affecting the highly hierarchical oral region known as the periodontium. It results in the gradual destruction of the tooth-supporting apparatus; periodontal ligament, cementum, and alveolar bone. Modern techniques can successfully limit the disease progression by targeting the microbial etiology of the disease; however, regeneration characterized by new cementum formation and periodontal ligament attachment remains elusive. Various novel tissue engineering approaches have been investigated for this purpose with an emphasis on patient-specific geometries, cellular and growth factor delivery, extracellular matrix formation, vascularization, and spatiotemporal degradation. This chapter reviews current developments in scaffold design for periodontal ligament tissue engineering, elaborating on the utilization of multiphase bioengineered scaffold recapitulating the hierarchical architecture of the native tissue. The chapter also describes the concepts and the recent advancements in whole tooth tissue engineering and explains the main challenges that this field is facing.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Handbook of Tissue Engineering Scaffolds: Volume One
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
