Abstract
It has been over 50years since Scrimshaw, Taylor and Gordon set out the bases for interpretation of synergistic and antagonistic interactions between malnutrition and infection. Any contemporary update must recognize emerging diseases such as HIV and re-emerging diseases such as tuberculosis. Genetic and epigenetic concepts and techniques have merged with the advance of technology in basic and applied immunity. Not only nutrient deficiencies, but also their excesses – including obesity and overweight – alter host defenses and risk of infections. Issues of vitamin D, host disease and infection, and interaction of the microbiome of fecal flora with the gut immune system represent two of the exciting contemporary departures.
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