Abstract
Nanoemulsions are defined as the heterogeneous dispersion of two immiscible liquids (oil in water or water in oil) with a mean droplet size in range of 20–200 nm that can be stabilized by different surfactants. Nanoemulsions are prepared by spontaneous emulsification method and high-energy emulsification methods mediated by high-pressure homogenizers and ultrasound generators. Nanoemulsions are considered as an attractive drug delivery system that is applicable for different administration routs including oral, parenteral, and transdermal. Recently, nanoemulsions gained more attention for intravenous delivery of wide variety of drugs due to their favorable properties such as biocompatibility, large surface area, improving the solubility of lipophilic drugs, enhanced pharmacokinetic parameters, drug delivery to targeted tissues by passive and/or active targeting, reduced toxicity, and the ability to alleviate the tumor drug resistance. In this chapter, after describing the characteristics of nanoemulsions, their structural and functional properties in intravenous administration for various drugs are described in detail.
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