239 Multi-functional in vitro and in vivo efficacy of Tiliacora triandra, natural ingredient with clinical anti-aging skin benefits

Abstract

Tiliacora triandra is a flowering plant also known as “bai yanang”. It is native to Southeast Asia and used particularly in the cuisines of northeast Thailand and Laos. Traditionally recommended for fever reduction and for relief from hangover. Pharmacological activities include anti-bacterial, anti-fungal, and anti-inflammatory properties, suggesting its adaptogenic function. The present study is to identify biological endpoints of proprietary extract of T.triandra. Testing in vitro in 3D skin model showed strong effect on hyaluronic acid production. After topical application of the ingredient in vivo, histological analysis of skin biopsy samples confirmed this observation. In addition effect on collagen production and epidermal turnover was also observed. In vivo bioinstrumentational analysis confirmed skin firming and wrinkle reduction benefits in a dermatologist-supervised, double-blind, randomized, placebo-controlled, split face clinical trial. Additionally, anti-inflammatory properties of T.triandra extract were confirmed by in vivo redness reduction assay. Interestingly, when tested in vitro, T.triandra was able to stimulate HSP70 pathway, confirming its potential not only as anti-aging but also adaptogenic ingredient, i.e. plant derived substance with protecting and balancing properties.