Abstract
Significant evidence from the epidemiological investigations showed that dietary polyphenols might manage and prevent type 2 diabetes. This review summarized the human studies and clinical trial of polyphenols as anti-diabetic agents. Polyphenols from coffee, guava tea, whortleberry, olive oil, propolis, chocolate, red wine, grape seed, and cocoa have shown anti-diabetic effects in type 2 diabetic patients by increasing glucose metabolism, improving vascular function, and reducing insulin resistance and HbA1c. However, the individual flavonoid and isoflavonoid compound looks like no effects on diabetes, although clinical and human data the intake of purified flavonoid and diabetes risk are limited. Preliminary clinical trials provided evidence that resveratrol has anti-diabetic activity in humans by improving glycemic control in humans with insulin resistance. Anthocyanins exhibited antidiabetic property by reducing blood glucose and HbA1c, increasing insulin secretion, and improving insulin resistance. The structure-activity relationship of polyphenols as anti-diabetic agents in human study is rarely reported.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
