2-Acylimino-3-alkyl-3 H-thiazoline derivatives: one-pot, three-component condensation synthesis of novel β-turn mimics

Abstract

One-pot, three-component condensation of aroylthiourea, primary amine and α-halocarbonyl derivatives for the synthesis of 2-acylimino-3-alkyl-3 H-thiazoline derivatives is described. This method is useful for simultaneously incorporating diverse functional groups at four positions in the 3 H-thiazoline skeleton to obtain β-turn tripeptide mimics.