Abstract
This paper describes fundamental investigation to apply penetration of micro-jet to disintegrate microcapsules in Drug Delivery System (DDS). Deformation processes of a bubble near curved elastic wall by underwater shock wave were observed by optical shadowgraph method using high-speed camera. It is found that a bubble generates micro-jet toward wall and opposite side whose characteristics are affected by wall elasticity, wall curvature and a position of an initial bubble. Maximum velocity reaches 93m/s, which corresponds to 37MPa as water pressure. Changing wall elasticity, wall curvature and an initial bubble position can control penetration force by micro-jet.
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