Abstract
Infection with adenovirus or exposure to adenovirus vectors induces antibodies that can interfere with gene therapy. Unfortunately, the most popular and widely studied adenovirus (human type 5) also has one of the highest prevalences of preexisting antibodies in humans. This chapter will review the surprisingly diverse mechanisms by which antibodies inhibit adenoviruses, the impact of antibodies on adenovirus vectors in vivo, and the many creative strategies that have been developed to try to mitigate the impact of antibodies on adenovirus vectors.
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