Abstract

Parasitic diseases cause significant global morbidity and mortality in humans and livestock annually. Accurate diagnosis of protozoan parasites hinges on understanding their localization within the host’s body. Protozoan parasites have high biotic potential, often expelled from the host through excretions such as feces, blood, or fluids, necessitating thorough examination. They inhabit various host sites: alimentary tracts (flagellates, coccidia), liver (Histomonas, Leishmania), spleen (Theileria), kidneys (coccidia), genital tract (Trichomonads), brain (Toxoplasma), blood (hemoprotozoa), reticuloendothelial system (Leishmania), muscles (Sarcocystis), and skin (Leishmania). Diagnosis involves sample examination, culture, blood tests, and molecular techniques. Chemotherapy’s challenges prompt interest in nanoparticle-based therapies. Nanotechnology manipulates particles at atomic scales, explored in treating protozoan diseases. This chapter provides a nanotech overview in managing human protozoan diseases, holding promise for innovative diagnosis and treatments.

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