12 - Effect of Dietary Fish Protein and Fish Oil on Azoxymethane-induced Aberrant Crypt Foci in A/J Mice

Abstract

This chapter highlights the effect of dietary fish protein and fish oil on Azoxymethane-induced Aberrant Crypt Foci in A/J Mice. In the study, male A/J mice is fed dietary fish protein and fish oil to examine the inhibitory effect of fish protein and its relationship with fish oil in the development of ACF induced by AOM in mice. The results suggest that fish protein, in combination with fish oil, may contribute to the beneficial health effects of fish consumption in protection against ACF formation. Daily supplementation of fish or fish products has a beneficial effect against chemically induced colonic preneoplastic progression in mice induced by AOM, which provides an effective dietary chemopreventive approach to disease management. However, other definitive bioassays, including protein and mRNA expression, are now in progress to establish surrogate end-point biomarkers in dietary fish-protein- and oil-product-mediated cancer chemoprevention. Currently, many reports are available on the nutritional properties of fish protein, including alteration of plasma cholesterol levels, lipoprotein metabolism, bile acid metabolism, and antioxidative effects. These attributes could be related to the mechanism of the chemopreventive effect of fish protein.