Abstract
Antimicrobial peptides (AMPs) are host defense peptides that exhibit antagonistic effects against broad spectrum microorganisms. Thousands of AMP sequences and structures are present across several AMP databases. Mammalian AMPs are mainly reported from primates, bovine, and other vertebrates, most of them falling under cathelicidins and defensins families. Mammalian AMPs can be classified based on peptide sequence, structure, and activity. The clinical applications of natural AMPs are restricted due to their relatively short half-life, toxicity, and hemolytic activity in the mammalian system. Still, the application of AMPs in dentistry, surgical procedures, wound healing, and related purposes are gaining importance with very few approved for clinical use and certain AMPs in the last stages of clinical development.
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