Abstract
Kininase activity of gingival tissue in normal subjects and in patients with periodontal disease has been measured quantitatively in order to clarify the relationship between various periodontal condition and the behaviour of the kininase activity.The kininase activity in either the homogenate or the aceton powder of gingival tissue was assayed by biological method of K. Takeya using guinea pig ileum.The following results were obtained;1) Kininase activity in gingival aceton powder individuals was less variable than the activity in the homogenate from fresh gingival tissues. However, both activities showed remarkable individual variation.2) Kininase activities either in the homogenate or the aceton powder of gingival tissues from 70 individuals were very high.3) Kininase activity of the gingival tissue in patients with periodontal disease was lower than that of normal tissue of the disease.From these results, it is speculated that the kininase activity of gingival tissue is closely related to the various periodontal condition, and it is also suggested from pharmacological actions of kinin and kininase that the kininase activity of gingival tissue may play an important role in the etiology and the progression of periodontal disease.
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