Abstract
Free α- and β-globins and haemoglobin biosynthesis 1. 1. Free α- and β-globins are precursors of haemoglobin biosynthesis. 2. 2. The addition, in physiological amounts, of rabbit α- or β-globin to a cell-free system from rabbit reticulocytes inhibits haemoglobin biosynthesis by reducing the homologous chain biosynthesis. Each free chain regulates its own rate of synthesis. The mechanism of this action is discussed. 3. 3. The added α- or β-globin is incorporated into the newly synthesised haemoglobin. The addition of α-globin activates haemoglobin β-chain synthesis but the addition of β-globin neither modifies nor inhibits haemoglobin α-chain synthesis. 4. 4. Evidence has been given that, in the cell-free system, the assembly of free α and β chains occurs. Nevertheless, the combination of free α chains with β chains still attached to the ribosomes is possible.
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