Abstract
β-Alanine has been found to inhibit the growth of Neurospora crassa, and this inhibition is reversed by carbamyl compounds. The wild strain and several arginineless mutants were inhibited 50 % by 0.005 M β-alanine. Pyrimidineless mutants displayed unusual behavior toward β-alanine. The pyr 3 strains, under certain growth conditions, were not affected by β-alanine. In contrast, the remaining pyr mutants were twice as sensitive to the inhibitor as was the wild strain. It is shown that the condition of insensitivity to β-alanine for the pyr 3 strains is the condition of arginine sensitivity. It is suggested that these results implicate carbamyl group metabolism as the site of β-alanine inhibition.
Published Version
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