虚血性心疾患の成因に関する研究 (第1報)

Abstract

This study was undertaken to evaluate the relationship between serum lipoprotein concentration and angiographic severity of coronary artery sclerosis in adult male.HDL-, LDL-, and VLDL-cholesterol were measured in normal subjects (N=47, average age 44 y/o), non-coronary heart disease (Non-CHD, N=23, average age 38 y/o) and coronary heart disease (CHD, N=72, average age 52y/o) by means of heparin-CaCl and O-phthaladehyde method.All patients of Non CHD and CHD were studied by selective coronary cine-angiography. And as an index of severity of coronary artery sclerosis, coronary score of modified Friesinger method was applied to those who underwent selective coronary cine-angiography. The results were as follows:1) HDL-cholesterol concentrations of CHD group was 28.5±7.3mg/dl and apparently lower than that of normal subject (47.5±10.4mg/dl) or of Non-CHD group (45.4±6.5mg/dl). LDL-cholesterol concentrations of CHD group, normal subjects and Non-CHD group were 140.3±30.7mg/dl, 121.1±27.1mg/dl, 117.9±27.4mg/dl, respectively.2) No significant correlation was found between HDL-cholesterol and coronary score among CHD group. However HDL-C/LDL-C ratio was inversely related to severity of coronary artery disease.In CHD group, all patients with less than 2.50 of the ratio (HDL-C/LDL-C×10) showed severe coronary artery sclerosis more than coronary score 5, whereas no patients with the ratio of over 4.0 showed severe coronary artery sclerosis.