Abstract
The article presents a method for calculating the parameters of acute toxicity of chemical and biological compounds using digital technologies. The software is designed to calculate the minimum tolerated dose, LD16, LD50, LD84, LD100 и SLD50 of chemical and biological compounds. Determination of acute toxicity parameters is one of the important stages in the creation of new biological and chemical compounds for the treatment and prevention of animal and human diseases. There are various GOST standards and methodological guidelines for determining the parameters of acute toxicity of biological and chemical compounds (GOST 32379–2020, interstate standard or GOST 32644–2014, test methods for the effects of chemical products on the human body). The automated method presented in the article for determining the parameters of acute toxicity makes it possible to standardize and automate the toxicological assessment of new medicines and is based on the "Methodological guidance, on toxicological assessment, of new drugs for the treatment and prevention of non-infectious animal diseases" dated January 29, 1987. The software can be used in research institutions engaged in the development of medicines for veterinary and medical use, feed additives and biologically active substances. The software can be used at enterprises engaged in the supervision of the production of veterinary and medical medicines. Program functionality: calculation of the minimum tolerated dose, LD16, LD50, LD84, LD100 и SLD50 chemical and biological compounds. Probit regression construction with visualization of the following data: LD0, LD16, LD50, LD84, LD100 .
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