Abstract
AbstractThis chapter describes the following three approaches used to study the tissue distribution of chemical and biological compounds in laboratory animals: (i) organ collection, homogenization/combustion, and liquid scintillation counting (LSC) analysis; (ii) whole‐body autoradiography (WBA), which includes quantitative whole‐body autoradiography (QWBA); and (iii) microautoradiography (MARG), which qualitatively resolves the localization of compounds to the cellular level in a histological preparation. LSC, WBA, QWBA, and MARG studies require the use of a radiolabeled chemical or biological test compound, which provides for the tracking and quantification of both the parent molecule and potential metabolites that might be formed. This chapter discusses the history, advantages, limitations, and examples of the application of each technique.
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