Повторний випадок неонатального сепсису в одній родині: випадковість чи прикра закономірність?

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Neonatal sepsis still remains an extremely relevant problem for newborns and a challenge for neonatologists and continues to take one of the prominent places of neonatal morbidity and mortality worldwide. The causes of neonatal sepsis are multifactorial and may have both maternal and other, unexplained causes. In recent years, numerous studies have been focused at studying the relationship between genetic variations and the frequency and causes of neonatal sepsis. Research are still continuous for study the role of genes associated with the formation of the inflammatory response in newborns. Research the role of genes associated with the formation of an inflammatory response in newborn children continues. Aim - to provide substantiated information on the problem of the features of the clinical course of neonatal sepsis with an analysis of literature data on possible genetic determinants of the occurrence of this disease in newborns using the example of a specific clinical case. The article presents a clinical case of fulminant sepsis in a newborn baby with a fatal outcome, which occurred repeatedly in the same family over two years with a similar clinical features and outcome. The authors tried to analyze the peculiarities of the neonatal sepsis, diagnostic procedures, treatment methods, causes of death and to link clinical and diagnostic findings with possible genetic disorders. The presented clinical case suggests the need for more in-depth studies involving geneticists and other specialists to predict the health of married couples and their future children. Conclusions. Identification of variations in genes involved in the bacterial-induced cellular response, as well as in the pathogenesis of sepsis, may allow the development of new diagnostic tools, improve the classification of sepsis, and more accurately predict the results of treatment in patients. Considering the mother's history, the course of the disease in the newborn, and the available clinical and laboratory examination data, a comprehensive in-depth genetic study of this married couple is mandatory. The study was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the children's parents was obtained for the research. No conflict of interests was declared by the authors.