Abstract
Background. To evaluate changes in acid-base balance in patients with coronary heart disease in the intraoperative period during coronary artery bypass grafting under artificial circulation using extracorporeal autohemomagnetotherapy (EAHMT). To consider the presence of a negative effect of this technique on acid-base balance. To study the possible relationship between the polymorphism of the angiotensin-1 receptor gene (AGTR1 A1166C), endothelin-1 (EDN1 Lys 198 Asn), endothelial nitric oxide synthase (NOS3 C786T) and changes in the studied parameters of acid-base balance. Material and methods. Group 1 included standard anesthesia for coronary artery bypass grafting under cardiopulmonary bypass without the use of EAHMT (60 patients). Group 2 included standard anesthesia for coronary artery bypass grafting under cardiopulmonary bypass with the use of EAHMT (63 patients). The following parameters of the acid-base balance of arterial blood were assessed: hydrogen index (pH), lactate (Lac), base deficit (SBE), potassium (K), sodium (Na), hemoglobin (Hb), hematocrit (Hct). All patients of both groups underwent intraoperative venous blood sampling from the central venous catheter. Then, the polymerase chain reaction method was used to study the genotypes of the angiotensin-1 receptor gene polymorphism (AGTR1 A1166C), endothelin-1 (EDN1 Lys 198 Asn), endothelial nitric oxide synthase (NOS3 C786T). Results. At the second stage of the study, a decrease in the hydrogen index of arterial blood, hemoglobin, hematocrit, and base deficit was revealed in both groups. A statistically significant increase in lactate and potassium was obtained in both study groups. No associations were found between the polymorphism of the angiotensin-1 receptor gene (AGTR1 A1166C), endothelin-1 (EDN1 Lys 198 Asn), endothelial nitric oxide synthase (NOS3 C786T) and the arterial blood acid-base balance. Conclusion. The use of EAHMT does not have negative impact on the electrolyte balance and acid-base composition of the blood. The presence of polymorphism of the AGTR1 gene A1166C (rs 5186), EDN1 gene Lys 198 Asn (rs5370), NOS3 gene C786T (rs 2070744) does not affect the acid-base balance of arterial blood.
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