Abstract
Chromatographic and spectrophotometric methods for the qualitative and quantitative analysis of thermosensitive liposomes loaded with doxorubicin have been developed. Lipids and doxorubicin in thermosensitive liposomes have been separated by thin layer chromatography TLC) in two systems: (i) chloroform - methanol - ammonia (65:25:4) and (ii) chloroform - methanol - glacial acetic acid - water (25:15:4:2). The chromatographic determination of sucrose in thermosensitive liposomes has been performed in 1,2-dichloroethane - anhydrous acetic acid - methanol - water (10:5:3:2) or isopropyl alcohol - acetone - ether - water (7:7:2:4) systems. A spectrophotometric assay of doxorubicin in thermosensitive liposomes has been validated.
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