Abstract

Cifelin is a hydrophobic anticancer drug. It is recommended to use this drug in high doses in order to achieve a therapeutic effect. Unfortunately, this treatment leads to a number of side effects. Inclusion of the drug in stealth liposomes reduces toxicity and ensures long circulation of cifelin in the bloodstream. In this study, the optimum molar ratio of component (165:8:1) was found for the liposomal membranes composed of phosphatidylcholine, cholesterol, and PEG-2000-DSFE, respectively. The possibilities of using liposome technology based on extrusion and sonication were compared. For cifelin liposomes with vesicle size about 150 ± 10 nm, the entrapment efficiency of 98.3% was estimated after sterilizing filtration of the dispersion. The liposome composition was confirmed by thin layer chromatography with a mobile phase consisting of butanol - glacial acetic acid - water (12:3:5) mixture.

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