Abstract
Background: Coronary artery disease (CAD) or coronary heart disease (CHD) is a major cause of mortality and morbidity for humankind. Genetic polymorphism of the rennin-angiotensin-aldosterone system (RAAS) affecting our circulation homeostasis may be potentially associated with coronary heart disease. So we investigated genetic polymorphism of aldosterone synthase gene (CYP11B2-344C/T), mineral corticoid receptor allele MR A4582C and MR G3514C among patients receiving coronary angiography. Materials and methods: We studied 609 unrelated patients receiving coronary angiography from April 2007 to March 2009. The collected data included genders, age, co-morbidities (hypertension and diabetes), and echocardiography measurements. Venous blood from each subject was obtained for genetic study. The CYP11B2 C-344T, MR G3514C and MR A4582C gene polymorphisms were determined by PCR-RFLP assay. Results: The proportion of type 2 diabetes mellitus and arterial hypertension was higher in patient with CAD. There were no significant differences in MR A4582C, MR G3514C, CYP 11B2 between the two groups. But CYP11B2-C/C allele was higher in the female group with CAD (10.2% vs 0%, p=0.01). Conclusion: In this study, male gender, hypertension and diabetes mellitus affect coronary heart disease a lot; and we found genetic polymorphism of aldosterone synthase gene (CYP11B2-344C/T) may alter coronary artery disease onset in female.
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