Abstract
Background and objectives. Peritoneal relapse (PR) is the most common pattern of gastric cancer (GC) recurrence after radical treatment. Currently, a variety of adjuvant intraperitoneal chemotherapy methods are being tested for their efficacy in reducing the level of PR. Methods. The radical treatment results of 226 patients with localized and locally-advanced GC have been analyzed. In order to select a group of patients with indications for adjuvant intraperitoneal therapy, a study of independent predictive factors and the development of a predictive PR nomogram for gastric cancer was completed. Results. As a result of the analysis of about three dozen potential factors in mono- and multivariate analysis, the impact on PR risk was confirmed by 4 independent predictive factors, namely: serosal invasion and its size (HR 9.36, p <0.001), morphological type according to Lauren (HR 5.3, p <0.001), index of regional lymph node involvement (HR 2.23, p = 0.015) and localization of the tumor in the stomach (HR 3.98, p <0,001). Conclusions. A predictive PR risk nomogram of gastric cancer after radical surgical treatment has been developed based on the identified independent factors, and it is of great clinical importance as a tool for segregating patients who require adjuvant intraperitoneal chemotherapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Shevchenko Scientific Society. Medical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
