Abstract
1% Lauromacrogol (LM) injection as hospital pharmacy product has been used as a sclerosing agent in the treatment of esophageal varices.LM, a polyoxyethylene ether is prepared by the additive polymerization of ethylene oxide with lauryl alcohol, and accordingly the possibility of degradation for sterilization is present.A high-performance liquid chromatographic (HPLC) method was presented for the separation and analysis of aldehydes in LM injection as their 2, 4-dinitrophenylhydrazones (DNPH). In spite of the sterilization of LM injection, FA and acetaldehyde (AA) were confirmed.Aliphatic carbonyl compounds were increased after the sterilization, especially AA was increased more than 20 times. A HPLC system for the determination of FA and AA with DNPH has been presented and this method provides a potentially very selective and sensitive method for the determination of these compounds in LM injection.
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