Abstract
Aim: to determine the association between the rs7799039, rs1137100, and rs1137101 polymorphic variants of the LEPR gene and serum leptin and its soluble receptor levels in patients with myocardial infarction (MI) and obesity. Patients and Methods: the study included 146 patients (108 men and 38 women) with an established MI, with a mean age of 57 (51; 64) years. The control group consisted of 300 conditionally healthy individuals (110 men and 190 women). The levels of leptin and its soluble receptor were measured by solid phase enzyme immunoassay Genetic analysis was performed using genomic DNA isolated from whole blood Polymorphic variants (rs7799039, rs1137100, rs1137101) of LEP and LEPR genes were genotyped by PCR with fluorescein-labeled probes Results: carrying the G allele of the polymorphic variant rs1137100 of the LEPR gene increases the risk of MI by 7 times in the recessive inheritance (odds ratio/OR=7.62, 95% confidence interval/CI 4.14-14.02). The rs1137101 variant of the LEPR gene has a protective effect in terms of the risk of MI. Furthermore, there were no significant differences in genotype rate between the groups of patients without obesity and with obesity The study found that individuals with the A/G and G/G genotypes of the rs1137100 variant of the LEPR gene had significantly higher levels of soluble leptin receptor (39.57 (30.59; 54.53) ng/mL) compared to those with the A/A genotype (24.29 (19.49; 34.70) ng/mL). Conclusion: the G allele of the LEPR gene is associated with an increased risk of MI and higher serum levels of soluble leptin receptor. These phenomena may be associated with a more unfavorable course of the cardio-metabolic continuum in these patients, particularly in those who are obese. KEYWORDS: myocardial infarction, leptin, polymorphic variant, leptin receptor, LEP, LEPR FOR CITATION: Hryachkova O.N., Khutornaya M.V., Sinitskaya A.V., Sinitskiy M.Yu., Kashtalap V.V. Polymorphic variants of LEP and LEPR genes in patients with myocardial infarction: association with serum leptin and its soluble receptor levels. Russian Medical Inquiry. 2024;8(1):4–8 (in Russ.). DOI: 10.32364/2587-6821-2024-8-1-1.
Published Version
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