Abstract
The purpose of this study was to analyze the changes of dysfunctional HDL structure and inflammatory factors caused by toll like receptor 4 (TLR4) protein expression in order to enhance heart function for cardiovascular disease prevention. The study groups were consisted of 40 Wistar old male rats at 50 weeks, and were divided into 4 groups as a control group (Con; n=10), control exercise group (Con+Ex; n=10), high fat diet group (HFD; n=10), and high fat diet exercise group (HFD+Ex; n=10). Dynamic resistance exercise training program included of ladder-climbing exercise and treadmill exercise, 3 days per week, for 12 weeks. The expression of aplipoprotein A-1 (ApoA-I) and TLR4 p rotein was analyzed by western blot. Also, plasma ApoA-I and C-reaction protein (CRP) concentration was analyzed by ELISA. The body weight before sampling of HFD-Ex group was significantly (p.05) lower than HFD group. ApoA-I protein expression and plasma ApoA-I concentration in heart muscle were not significantly different between all groups. However, TLR4 protein expression and plasma CRP levels in heart muscle were significantly (p.05) decreased in the HFD-Ex group compared to the HFD group. Therefore, dynamic resistance exercise increases heart muscle function and reduces inflammatory cytokine secretion. However, additional protein analysis related to the function of dysfunctional HDL is needed and further studies will be needed.
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