Abstract
According to the literature, a pattern of increased activation of VEGF growth factors and a decrease in the level of BDNF in blood serum in the early stages of DR was revealed, which is a good diagnostic marker for detecting DR in the early stages. Purpose. To study the indicators of biomarkers (BDNF and VEGF) in the blood serum and features of retinal microcirculation in patients with type 2 diabetes in the absence of clinical signs and varying degrees of severity of DR and to determine their diagnostic and prognostic value. Material and methods. A clinical study was conducted among 252 people (n = 504), of which 168 patients with type 2 diabetes and 84 healthy individuals, the average age of which was 57.6 ± 7.8 years old, of which 52.6 % were men, 47,4 % women. Results and conclusion. As a result of the study, it was proved that a mild BDNF deficiency in the SC less than 0.62 ng/ml indicates general DR, and a BDNF level < 0.22 ng/ml indicates the development of PDR and/or diabetic macular ischemia (DMA). Keywords: diabetic retinopathy, vascular growth factor VEGF, brain-derived neurotrophic factor BDNF, biomarkers for the development of DR
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